Ovarian Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Ovarian Cancer, including details on symptoms, causes, treatment, information.

Lessons from controversy: ovarian cancer screening and serum proteomics.

Ransohoff DF

Department of Medicine, University of North Carolina at Chapel Hill, CB# 7080, Bioinformatics Bldg. 4103, Chapel Hill, NC 27599-7080, USA. ransohof@med.unc.edu

In 2002 a study reported that a blood test, based on pattern-recognition proteomics mass spectroscopy analysis of serum, was nearly 100% sensitive and specific to detect ovarian cancer. Plans to introduce a commercial screening test by early 2004 were delayed amid concerns about whether the approach was reproducible and reliable. In this issue of JNCI, two commentaries discuss whether the initial results are reproducible and whether bias may account for results. This essay describes how threats to validity from chance and bias may cause erroneous results and inflated expectations in the kind of observational research being conducted in several "-omics" fields to assess molecular markers for diagnosis and prognosis of cancer. To address such threats and to realize the potential of new -omics technology will require application of appropriate rules of evidence in the design, conduct, and interpretation of clinical research about molecular markers.

Published 16 February 2005 in J Natl Cancer Inst, 97(4): 315-9.
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