Ovarian Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Ovarian Cancer, including details on symptoms, causes, treatment, information.

Stromal osseous metaplasia in a low-grade ovarian adenocarcinoma.

Mukonoweshuro P, Oriowolo A

Department of Histopathology, Level 04, Derriford Hospital, Derriford Road, Plymouth PL6 8DH, UK. pinini@doctors.org.uk

BACKGROUND: Stromal osseous metaplasia is a rare and curious finding in tumors of the ovary. CASE REPORT: The patient, a 66-year-old P3 G3 white female, had a past history of stage 1c left ovarian, well-differentiated endometrioid adenocarcinoma removed in 1981. She was treated with radiotherapy. The tumor recurred 21 years later with prominent stromal osseous metaplasia that had not been present in the primary. DISCUSSION: The pathogenesis of osseous metaplasia in epithelial tumors of the ovary is unclear; however, it is probable that a metaplastic process involving multipotential stromal stem cells results in bone formation. CONCLUSION: Benign osseous metaplasia in ovarian tumors is rare and its histogenesis remains unclear. As far as we know, this process does not appear to have any prognostic or pathological significance.

Published 26 September 2005 in Gynecol Oncol, 99(1): 222-4.
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