Ovarian Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Ovarian Cancer, including details on symptoms, causes, treatment, information.

Interferon beta adenoviral gene therapy in a patient with ovarian cancer.

Sterman DH, Gillespie CT, Carroll RG, Coughlin CM, Lord EM, Sun J, Haas A, Recio A, Kaiser LR, Coukos G, June CH, Albelda SM, Vonderheide RH

Thoracic Oncology Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA.

Background A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon beta gene therapy.Investigations Abdominal and chest CT scans, 2-[(18)F]fluoro-2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses.Diagnosis Stage IV ovarian cancer with malignant ascites and pleural effusion.Management Tunneled pleural catheter and intrapleural adenoviral-mediated interferon beta gene therapy.

Published 2 November 2006 in Nat Clin Pract Oncol, 3(11): 633-9.
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